Deferoxamine (mesylate)
Deferoxamine is a bacterial siderophore that chelates iron.{23098} It is used to experimentally inhibit iron-dependent prolyl hydroxylases (EC50 = 17.8 µM), thus preventing the degradation of isoforms of hypoxia inducible factor during normoxia.{23099,8840,23097} Deferoxamine has applications in diseases that are characterized by high levels of circulating iron, such as thalassemia major.{23096}
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