Ciclopirox
Ciclopirox is an iron chelator, antifungal, and anticancer agent.{26941,41490,53131,53132} It inhibits the iron-dependent enzyme hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; IC50 = 1.58 ?M), an effect that is reduced in the presence of iron.{26941} It stabilizes hypoxia-inducible factor-? (HIF-1?) under normoxic conditions in rat glomus cells when used at a concentration of 5 ?M.{33213} Ciclopirox is active against clinical isolates of T. rubrum, T. mentagrophytes, and C. albicans (MICs = 0.03-0.5, 0.03-0.5, and 0.06-0.5 ?g/ml, respectively) and inhibits growth of T. mentagrophytes on porcine skin ex vivo when applied topically.{41490,53131} It inhibits proliferation of Rh30, HT-29, and MDA-MB-231 cells in a concentration-dependent manner and halts the cell cycle at the G1/G0 phase and induces apoptosis in Rh30 cells.{53132} Ciclopirox (25 mg/kg) reduces tumor growth in an MDA-MB-231 mouse xenograft model. Formulations containing ciclopirox have been used in the topical treatment of fungal infections.
Do you have any questions about this product?
Order your product by email
Productname
Ciclopirox
16021-250
By filling out this form, you are placing an order by e-mail. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
Request a sample
Productname
Ciclopirox
16021-250
By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
Are you looking for specific products, alternatives or documentation?
