SB 202190 (hydrochloride)

SB 202190 is a potent, selective, and cell-permeable inhibitor of p38 MAP kinases, inhibiting p38? (SAPK2A, MAPK14) and p38? (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively.{21464,12847} When tested at 10 ?M, SB 202190 has negligible effects on a range of other kinases, including other MAP kinases such as ERK and JNK.{12847} It directly binds to the ATP binding pocket of p38 MAP kinases.{15221} SB 202190 has been used to elucidate the roles of p38 MAP kinases in inflammatory cytokine expression, nicotine-induced receptor expression, and HIV-mediated depressive disorder.{21463,21466,21467}