5(S)-HETE
5(S)-HETE is produced by the action of 5-LO on arachidonic acid to give 5(S)-HpETE, followed by reduction of the hydroperoxide. 5(S)-HETE has proliferative and chemotactic effects on granulocytes.{556} When further metabolized to 5-oxoETE, it is a more potent eosinophil chemoattractant than leukotriene B4.{1329,2090}
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