HumanKine recombinant human IFN gamma protein

Interferon gamma (IFN ?), is a type II interferon that provides immunity against bacterial, viral and protozoan infections. In its active form, IFN ? is a glycosylated, non-covalently linked homodimer of 29-32 kDa subunits. It is produced by a number of immune cell types including natural killer cells, natural killer T cells, and effector lymphocyte T cells following antigenic and inflammatory triggers. The IFN ? dimer binds to its cognate receptor which has two subunits: IFN-?R1 which is the ligand-binding chain (? chain) and IFN-?R2, the signal-transducing chain (? chain). Binding to the receptor activates the JAK/STAT pathway which in turn activates IFN ? responsive genes. While IFN ? can inhibit viral replication, it also works as an immune-modulator and immune-stimulator by increasing surface expression of class I MHC proteins (PMID: 19268625; 10688427)